• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Equipment and method of tomography generation. The proposed equipment and method allow, with very limited data (very few projections), in a limited angular range of source and detector movement and high mechanical tolerance (to inaccuracies in the positioning of source and detector) obtaining high-resolution tomographies. Quality. The equipment comprises an x-ray image device with source set (1) -detector (2) of x-rays with movement, a surface scanning device (4), and a control and data processing system configured for execute at least one routine of generation of tomographies. The method comprises a routine for adjusting the geometric calibration of the equipment and a routine for reconstructing a tomography with the images and surface data obtained by the equipment. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2646687A1
    申请号:ES201730341
    申请日:2017-03-15
    公开日:2017-12-14
    发明作者:Manuel Desco Menéndez；Mónica ABELLA GARCÍA
    申请人:Universidad Carlos III de Madrid；Fundacion para la Investigacion Biomedica del Hospital Gregorio Marañon；
    IPC主号:
    专利说明:

    OBJECT OF THE INVENTION
    The present invention is part of the technical field of diagnostic imaging devices. More specifically, a device and a method that allow obtaining a 3D image from a limited number of projections and angular range using X-ray imaging systems are described. BACKGROUND OF THE INVENTION
    A "C-arc" imaging system allows you to obtain flat 2D images that do not provide depth information. These types of systems comprise at least one X-ray generator and an image capture system mounted on an arc-shaped arm. They also include a work unit in which images are visualized, stored and manipulated.
    Some of the advantages of these systems are, for example, that they have an open design that allows the “C” shaped arch to be placed around a patient who is lying on a bed or an operating room table, which are compact and are Very economical compared to other medical imaging equipment. Thanks to its open design, these types of systems are currently used as a tool to obtain an image of a patient in the operating room.
    Two of the main technical problems associated with obtaining 3D images with equipment designed for flat image are the following:
    -  the equipment may suffer mechanical stresses that change the relative positions of the source and the detector for each projection position, without these being repeatable for successive acquisitions (high mechanical tolerance), making geometric calibration difficult; Y
    -  in general they are not designed to take enough projections around the patient, necessary to obtain a good image quality using methods


    Conventional reconstruction
    In recent years, attempts have been made to develop specific instrument-based systems that combine portable X-ray equipment with digital detectors for intraoperative 3D imaging (such as the Ziehm Vision FD Vario 3D®, the Siemens Arcadis Orbic Orbital Rotation® or the O -arm of Medtronics®). However, these systems maintain strict mechanical precision requirements, generally only allow isocentric rotations and cover a high angular range (135 degrees or more).
    It is also known from the prior art, document DE102012209422A1 which describes an X-ray system comprising an X-ray emitter and a detector, each arranged at one end of an "C" shaped arc to take images during surgical interventions, as well as a transmitter and a receiver of Terahertz that allow to determine the surface of the patient under study and a control device that uses the information of the surface obtained during reconstruction and / or evaluation processes.
    Related to this patent are known documents DE102010010192A1 and US2012294504A1 that respectively describe an apparatus consisting of a transmitter and receiver of Terahertz and a processing unit that represents the irradiated surface and a method for obtaining artifact-free 3D images in truncation situations by completing data with patient surface information or determine the relative position of the patient.
    The previous documents describe a lightning system with a surface scanning system for surgical situations in which the surface is used for the correction of the truncation device or for patient positioning among others. Solutions to eliminate artifacts by reduced angle or few projections are not described. In addition, solutions for the calibration problem are not described due to lack of mechanical precision (high values of mechanical tolerance that do not guarantee the repeatability of the source and detector trajectory).
    Document US2011255765A1 describes an x-ray system with a surface detector to compensate for metal artifacts in dental studies based on the registration of


    the surface of the teeth with the reconstructed image (eliminating points on the reconstructed image that fall off the surface). This document does not propose solutions to advanced reconstruction problems for low dose with limited angle and / or few projections, or for calibration due to lack of mechanical precision (high values of mechanical tolerance that do not guarantee the repeatability of the source path and detector).
    Other known patents that make use of a surface scanner are for example US 20130034203A1 which describes a method for obtaining a simulation image of the anatomy of an experimental animal based on the registration of the surface of the animal with an atlas, and the apparatus for acquiring the necessary data for the surface; US2010010757A1 which describes the use of a surface scanner to collect part of the data necessary to obtain attenuation maps; and US2016148398A1 which allows correction of displacements in projection data due to geometric deformation and vibration of a C-arc in a short time. DESCRIPTION OF THE INVENTION
    The present invention describes an equipment and a method of generating tomographs from the data obtained with an X-ray imaging device, which can have high mechanical tolerance, and a surface scanning device.
    The tomography generation equipment of the present invention comprises:
    -  an x-ray imaging device that in turn comprises:
    - a source of X-rays,-a x-ray detector,and the x-ray source or the x-ray detector or both move alonga predefined orbit around the body or body part you wantgenerate the tomography;
    -  a surface scanning device configured to obtain data from the body surface or body part under study. This device can be attached to the X-ray source, the X-ray detector or it can be totally independent of them, including the possibility of being held and moved manually.


    - a control and data processing system configured to execute at least one geometric calibration routine and a tomography generation routine from data obtained by the imaging device and the surface scanning device.
    Throughout the memory, when the terms "source" and "detector" are used they refer to the X-ray source and the X-ray detector. Also, when referring to the body from which the source is to be generated Tomography is referring to a whole body or a part of it.
    It is key to the invention that the images obtained with the X-ray imaging device are digital, so in an embodiment of the invention the detector is a flat-panel digital detector. In another embodiment of the invention, the X-ray imaging device comprises an analog detector and in this case the X-ray imaging device needs to include an image digitizing element.
    The X-ray source and the X-ray detector can be moved independently, each following a predetermined trajectory, or with a solidarity movement (for example in cases where the source and the detector are linked together solidarity with a frame). The X-ray imaging system can be of the TAC type, “C-arc”, digital radiology system with a suspension system that allows the source and detector to be moved around the sample, etc.
    The surface scanning device may be of the type of those that are in contact (such as those in the form of pointers with markers that follow the optical positioning systems) or of the type of those that are non-contact (based on a device of Conoscopic holography, such as the ConoProbe Mark®, in structured light, such as 3D Artec Eva®, or in other types of non-ionizing radiation, such as the Terahertz image, or even ionizing, such as very low dose RX).
    The method of the present invention comprises initial steps of:a) perform a geometric calibration of the X-ray imaging device; Yb) obtain images with the X-ray imaging device.


    Also, the method comprises the following stages:c) obtain data from a surface of a body with the scanning device ofsurface;
    d) obtain a 3D body mask from the surface data obtained with the
    surface scanning device;e) adjust the geometric calibration of the X-ray imaging devicepreviously obtained with the images obtained by it and the surface dataobtained by the surface scanning device;
    f) reconstruct a tomographic image from the images obtained with theX-ray imaging device combined with surface dataobtained with the surface scanning device.
    Thanks to the combination of the equipment and the method described, with very limited data (veryfew projections), in a limited angular range of movement of the source anddetector and high mechanical tolerance (to inaccuracies in source positioningand detector, allowing position errors greater than 1 mm and 1 degree) are obtainedresults equivalent to those obtained with traditional TACs or other equipmentX-ray specific for 3D, in which the source-detector set rotates 192º (“shortscan ”) or 360 degrees (“ full scan ”).
    One of the advantages of the present invention is that the equipment has a lower requirementof angular range of rotation of the source-detector set. This is especiallyadvantageous in cases where there are mobility difficulties of the patient (in the UVI
    or during surgery, for example, where portable C-arch systems are usually used that allow 2D image acquisition but are not designed to obtain 3D image).
    Likewise, the equipment and the method make it possible to use lower doses of radiation for the patient by obtaining an adequate quality tomography with fewer projections. Another associated advantage is that it allows to increase the acquisition speed of the tomographs by obtaining images of adequate quality with less angular range of rotation of the source-detector assembly, facilitating the realization of dynamic studies.


    Additionally, the equipment and method allow extending the use of pre-existing 2D radiology systems by allowing tomographic capabilities to be incorporated into them. In addition, the tomography generation equipment can be portable if the X-ray imaging device is a C-type arc.
    Finally, the present invention has fewer requirements for mechanical tolerance in the source and detector positioning, since the proposed calibration adjustment method makes it possible to correct variations in the positions of the X-ray imaging device (source and detector) in successive acquisitions. This allows cost reduction, an especially important advantage in veterinary applications or in developing countries with few resources.
    In the equipment and methods known in the state of the art, it is necessary to perform a periodic calibration that is valid in subsequent acquisitions since they have a sufficiently low mechanical tolerance to guarantee the repeatability of the source and detector path that allows avoiding the occurrence of systematic errors in images (artifacts) below half a millimeter and the tenth degree in displacements and rotations of source or detector.
    In the state of the art there is no solution to the problem of geometric calibration in cases of high mechanical tolerance of the equipment. Also, in the state of the art no systems are described that allow the elimination of artifacts by reduced angle or few projections. DESCRIPTION OF THE DRAWINGS
    To complement the description and in order to help a better understanding of the features of the invention, according to some preferred embodiments thereof, a set of drawings is attached as an integral part of said description where, for illustrative purposes and not limiting, the following has been represented:
    Figure 1a.- Shows a view of an embodiment of the equipment for generating


    CT scans
    Figure 1b.- Shows a view of another embodiment of the tomography generation equipment with the image scanning device arranged in another position.
    Figure 2.- Shows a flow chart of the tomography generation method.
    Figure 3.- Shows graphs with a result obtained with the calibration adjustment method for two geometric parameters (horizontal displacement and detector rotation).
    Figures 4a.- Shows sagittal, coronal and axial cuts of the 3D reconstruction of a body generated from the data obtained with the X-ray imaging device by a prior art method, before performing the adjustment of calibration.
    Figure 4b.-Shows sagittal, coronal and axial sections of the 3D reconstruction of a body generated by the same method of the state of the art as in Figures 4a, after having made a calibration adjustment.
    Figure 4c.-Shows views of sagittal, coronal and axial sections of the 3D reconstruction of a body generated by the complete tomography generation method of the present invention. PREFERRED EMBODIMENT OF THE INVENTION
    Next, with the aid of Figures 1 to 4, examples of embodiment of the equipment and the tomography generation method of the present invention are described. Likewise, the results of tomography are shown (views of sagittal, coronal and axial cuts of 3D reconstructions of a body) generated from the data obtained with an X-ray imaging device using a prior art method ( FDK) and by the different stages of the tomography generation method of the present invention.
    A first object of the invention is the tomography generation equipment. In the


    Figure 1 shows an example of embodiment of said equipment comprising at least one X-ray imaging device, a surface scanning device and a control system.
    The X-ray imaging device comprises an X-ray source (1) and a digital X-ray detector (2); one of these elements or both have movement.
    The X-ray source (1) and the digital X-ray detector (2) are facing each other in the imaging device and between them the body (5) of which the tomography is to be generated is placed. The X-ray source (1) or the X-ray detector (2) or both move along a predefined orbit (3) around the body (5) that can be isocentric or non-isocentric. Figures 1a and 1b show exemplary embodiments in which the orbit (3) is not circular and the X-ray source (1) and the X-ray detector (2) move independently of each other.
    The movement of the X-ray source (1) or of the X-ray detector (2) or both is what allows 2D images of the body (5) to be obtained from different views or projection angles. As described previously, the equipment and method proposed here allow to obtain tomographs of adequate quality even in cases in which the movement of the source-detector assembly is limited to a small range of views.
    The equipment also comprises a surface scanning device (4) configured to obtain body surface data (5) under study. Said surface scanning device (4) can be arranged in various positions of the equipment (attached to the X-ray source, the X-ray detector or be totally independent, including the possibility of being held and moved manually) without that this limits the correct obtaining of the surface.
    .
    The equipment also includes a control and data processing system configured to execute at least one geometric calibration routine and a tomography generation routine. Preferably, the tomography generation routine that


    runs in the data control and processing system comprises at least thefollowing stages:-a geometric calibration adjustment stage-a stage of advanced image reconstruction
    A method of generating tomography is also the subject of the present invention.with the tomography generation team. The tomographs are generated from thedata acquired with the imaging device and the scanning devicesurface. The different stages of the method are shown in Figure 2.
    The initial stages of the method are:a) perform a geometric calibration of the equipment;b) obtain digital images with the X-ray imaging device
    Step a) of geometric calibration of the equipment allows to determine the exact positionof the X-ray source and the X-ray detector for each view. This stage is doneperiodically in the team.
    In an exemplary embodiment, the method could also comprise an initial stage ofPreprocess the images obtained with the X-ray imaging device,in case the detector obtained images in raw raw data.
    Subsequently, the method comprises performing the following steps:
    c) obtain data from a surface of a body (5) with the scanning devicesurface (4);d) obtain a 3D mask of the body (5) from which the tomography is to be generated, a
    from the surface data obtained with the surface scanning device (4);e) adjust the geometric calibration of the equipment previously performed by
    images obtained by the x-ray imaging device and data fromsurface obtained by the surface scanning device (4);f) reconstruct a tomographic image from the images obtained with the
    X-ray imaging device combined with surface data


    obtained with the surface scanning device (4).
    In order for the positions obtained from source and detector to be valid for subsequent acquisitions, it is necessary to guarantee a sub-millimeter mechanical tolerance in linear displacements of the source and / or the detector and below the degree in rotational displacements of the source and / or the detector In case the mechanical tolerance of the equipment is above these values, it is necessary to adjust the geometric parameters such that they represent the real positions of the source and the X-ray detector during the acquisition of the images with the image taking device by X-rays. Therefore the step of adjusting the geometric calibration of the equipment (step e)) is essential in the described method.
    Said step of adjusting the geometric calibration of the equipment preferably comprises the following sub-stages:
    i) make a preliminary reconstruction of the images obtained with the X-ray imaging device using the initial calibration file obtained in the initial stage a);
    ii) make a 3D record with the mask obtained from the data obtained with the surface scanning device; iii) simulate the projection of the registered mask obtained in the sub-stage iii) with the initial calibration file obtained in the initial stage a); Y
    iv) make a rigid recording of the projection of the registered mask obtained in the sub-stage iii) and of the images obtained with the X-ray imaging device projection to projection;
    v) correct the initial geometric calibration file obtained in the initial stage a) with the registration values obtained in sub-stage iv) to obtain an adjusted calibration file.
    In an exemplary embodiment, step b) is performed by a conventional FDK type reconstruction method with the initial geometric calibration file obtained in step a).
    Figure 2 shows all the steps of the key stages of the present invention which are the steps of adjusting the calibration of the equipment (step e), previously


    described, and of reconstructing the tomographic image from the few projections obtained with the X-ray imaging device and with the surface data obtained with the surface scanning device (step f)). These steps of the method are those that allow to obtain a tomographic image of adequate quality despite starting from few images (few projections) and obtained in limited positions (limited angular range of motion of the detector source assembly) with the equipment of the invention with low requirements of mechanical tolerance.
    In an example of tomography generation using a device like the one shown in figure 1, in order to achieve the different projections (2D images) with the X-ray imaging device, the X-ray source (1) and the detector are moved X-ray (2) together following a quasi-circular orbit (3) around the body (5) since in this example the source and the detector are attached to a frame. In this exemplary embodiment, in order to obtain the images of figures 4a-c 42 projections are distributed evenly over a 120 degree angular range.
    Figure 3 shows the result of the first key stage of the tomography generation method of the invention, which is the step of adjusting the calibration from the surface data obtained. The figure shows the values of two of the main geometric parameters, horizontal displacement and rotation of the detector (2), for two different geometric calibrations before and after the calibration adjustment.
    Figure 3 shows the difference in geometric parameters for the same X-ray imaging device obtained by calibrating at two different times (lack of mechanical precision in the X-ray imaging device) and the need for step e) of the tomography generation method of the invention, which is the step of adjusting the calibration from the surface data obtained. In one of the graphs of figure 3, the horizontal displacement in millimeters corresponding to each projection angle, in degrees, has been represented. In the other graph the rotation has been represented, in degrees for each projection angle, also in degrees. In both cases, the dashed line with stripes represents a first calibration and the dashed line with stripe-dot-line represents that same first but adjusted calibration. Also, the dashed line with dot-dot-dot-ray represents a second calibration and the solid line represents that same second


    Calibration but adjusted. After the calibration adjustment, the parameters match the current position of the X-ray imaging device at the time of obtaining the body images.
    5 Figure 4a shows the results obtained with the equipment for obtaining2D images using a prior art method, before adjustingcalibration. Figure 4b shows the results obtained with the same equipment andprior art method as in figure 4a after performing the step of adjusting theCalibration from images and surface data previously obtained.
    10 An example of quality tomography obtained with the equipment and method of the invention can be seen in Figure 4c. As can be seen in this figure, the reconstructed image is of high quality despite being generated without guaranteeing the mechanical precision that allows the repetitiveness of the source and detector trajectory and
    15 from very limited data.
    In this case, an adequate quality tomography has been obtained with only 42 projections compared to the more than 400 projections that are usually performed in the state-of-the-art TACs. In addition the angular range in which the movements have been made
    20 of the source-detector set has been 120º compared to the usual 360º for the acquisitions with the state of the art equipment or the 195º necessary in a short acquisition (“short scan”).
    In this embodiment, a reconstruction method based on the
    25 minimization of the Total Variation (TV) function subject to restrictions: (a) data fidelity and (b) result contained in the mask generated from the data obtained by the surface scanning device (4). In this case the following formulation has been used:
    min u s.t. uò ȍ, Au f
    2 ı
    ’

    ’U’Xu 2’ yu 1 2


    X-ray image, ı2 is the noise in this data and ȍ is the mask generated from the data acquired with the surface scanning device. The resolution of the minimization problem has been done using the Split Bregman formulation.

    权利要求:
    Claims (7)
    [1]
    1.- Tomography generation equipment comprising:
    - an X-ray imaging device which in turn comprises:5 - an X-ray source (1),
    - an X-ray detector (2),and the x-ray source (1) and the x-ray detector (2) are facing each othereach other to receive between them a body (5) from which thetomography;
    10 - a surface scanning device (4) configured to obtain the body surface (5),
    -  a control and data processing system configured to execute at least one geometric calibration routine and a tomography generation routine from the data obtained by the X-ray imaging device and the
    15 surface scanning device (4).
    [2]
    2. Equipment for generating tomographs according to claim 1, characterized in that the movement of the X-ray source (1) or the X-ray detector (2) or both is carried out in an isocentric orbit (3) around the body (5).
    3. Equipment for generating tomography according to claim 1, characterized in that the movement of the X-ray source (1) or of the X-ray detector (2) or both is carried out in a non-isocentric orbit (3) around of the body (5).
    Equipment for generating tomography according to claim 1, characterized in that the movement of the X-ray source (1) and the movement of the X-ray detector are independent, each of them or both being able to move with a predetermined trajectory .
    5. Tomography generation equipment according to claim 1, characterized in that the movement of the X-ray source (1) and the movement of the X-ray detector (2) are integral.

    [6]
    6. Tomography generation equipment according to claim 1 characterized in that the surface scanning device (4) is a scanning device with contact.
    [7]
    7. Tomography generation equipment according to claim 1 characterized in that the surface scanning device (4) is a contactless scanning device.
    [8]
    8. A tomography generation equipment according to claim 1, characterized in that the tomography generation routine comprises at least the following stages:
    -  a step of adjusting the geometric calibration of the equipment;
    -  An advanced stage of image reconstruction.
    [9]
    9.- Tomography generation method with the tomography generation equipment ofclaims 1 to 8 comprising the steps of:a) perform a geometric calibration of the equipment;b) obtain images with the X-ray imaging device;
    and is characterized in that it subsequently comprises the following stages:c) obtain data from a surface of a body (5) with the scanning devicesurface (4);
    d) obtain a 3D body mask (5) from the surface data obtained
    with the surface scanning device (4);e) adjust the geometric calibration of the equipment previously obtained with the imagesobtained by the x-ray imaging device and surface dataobtained by the surface scanning device (4);
    f) reconstruct a tomographic image from the images obtained with theX-ray imaging device combined with surface dataobtained with the surface scanning device (4).
    [10]
    10. Method of generating tomography according to claim 9 characterized in thatThe step of adjusting the geometric calibration of the equipment includes the followingsubcaps:i) make a preliminary reconstruction of the images obtained with the device

    X-ray imaging using the initial calibration file obtained in the initial stage a); ii) make a 3D record with the mask obtained from the data obtained with the surface scanning device; 5 iii) simulate the projection of the registered mask obtained in sub-stage iii) with the initial calibration file obtained in the initial stage a); Y
    iv) make a rigid recording of the projection of the registered mask obtained in the sub-stage iii) and of the images obtained with the X-ray imaging device projection to projection;
    10 v) correct the initial geometric calibration file obtained in the initial stage a) the registration values obtained in sub-stage iv) to obtain an adjusted calibration file.



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    同族专利:
    公开号 | 公开日
    WO2018167348A1|2018-09-20|
    ES2646687B1|2018-10-26|
    EP3542722A1|2019-09-25|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    WO1997016721A1|1995-11-02|1997-05-09|Analogic Corporation|Computed tomography scanner with reduced power x-ray source|
    WO2002056752A2|2001-01-19|2002-07-25|Chin-Ann Cheng|X-ray computer tomography scanning system|
    US20110255765A1|2010-04-20|2011-10-20|Carlson Bradley S|Reduction and removal of artifacts from a three-dimensional dental x-ray data set using surface scan information|
    US20140334700A1|2011-07-01|2014-11-13|Carestream Health, Inc.|Methods and apparatus for scatter correction for cbct system and cone-beam image reconstruction|
    DE102005005087B4|2005-02-03|2012-09-27|Siemens Ag|Method for correcting non-reproducible geometry errors of an X-ray C-arm machine|
    EP2326250B1|2008-08-13|2017-01-11|Koninklijke Philips N.V.|Calibration method for ring artifact correction in non-ideal isocentric 3d rotational x-ray scanner systems using a calibration phantom based rotation center finding algorithm|
    DE102012209422B4|2012-06-04|2019-04-25|Siemens Healthcare Gmbh|X-ray device with terahertz measuring device and method|
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    PCT/ES2018/070194| WO2018167348A1|2017-03-15|2018-03-15|Device and method for generating tomograms|
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